Endocrine Abstracts

We describe a 40-year-old female who presented with fine tremors, weight loss, dyspnea and hemoptysis. On examination she appeared diaphoretic and tachycardic without goiter or thyroid eye disease. Thyroid function tests confirmed biochemical hyperthyroidism: [fT4 >100 pmol/l (NR: 12–22), TSH <0.005 mu/l (NR: 0.270–4.200)]. Chest X-ray showed numerous metastatic pulmonary nodules bilaterally. CT chest confirmed multiple large pulmonary metastases throughout both ...

Hypercalcemia is a relatively common extrapulmonary manifestation of sarcoidosis. Sarcoidosis-associated hypercalcemia is due to the uncontrolled synthesis of 1,25-dihydroxycholecalciferol and increased intestinal absorption of calcium which usually results in a low serum concertation of parathyroid hormone (PTH). High levels of PTH in patients with hypercalcemia secondary to sarcoidosis is usually an indication of co-existent primary hyperparathyroidism. We present a case of ...

Total parathyroidectomy with autotransplantation of parathyroid tissue is one of the treatment modalities for primary hyperparathyroidism in Multiple endocrine neoplasia type 1 (MEN1). Many of these patients are young and recurrence may take decades to emerge. We present a case of a 45-year-old woman who was diagnosed with MEN syndrome type 1 at the age of 12. Over the years, she underwent multiple surgical interventions including pituitary macroprolactinoma resection resultin...

Introduction: Screening patients with type 1 diabetes (T1DM) for other autoimmune diseases such as thyroid disorders has been recommended by international guidelines. Data from the Middle East is currently limited. This study aims to identify the pattern and prevalence of thyroid disorders among the UAE population with T1DM.Method: A retrospective cohort study was conducted looking at all adult patients (age ≥16 years) attending Imperial College Lo...

Graves’ disease is an autoimmune disorder of the thyroid gland. Patients with type 1 diabetes (T1DM) are at a higher risk of developing autoimmune diseases including thyroid disorders. To our knowledge, diagnosing Graves’ disease at the same time in a monozygotic twin with T1DM is a rare occurrence. We present a case of monozygotic female twin with T1DM, who both developed Graves’ disease at the same time. Type 1 diabetes was diagnosed in one of the twins (twin ...

Introduction: Limited data is available on Liraglutide as a treatment option for weight regain after bariatric surgery. We aim to report the efficacy of Liraglutide as a treatment for weight regain in UAE population who underwent bariatric surgery.Methods: Retrospective analysis was performed on all patients with weight regain after bariatric surgery who received Liraglutide (dose range 0.6 up to 3.0 mg/day) while attending bariatric clinic of Sheikh Kha...

Introduction: Iatrogenic Cushing’s syndrome (ICS) can be caused by virtually all forms of steroid treatment with or without suppression of hypothalamic–pituitary–adrenal (HPA) axis. Here we report betamethasone nasal drops used as treatment post septorhinoplasty as a cause of iatrogenic Cushing’s syndrome.Case: A 36 years old female with background history of depression presented to endocrinology clinic for evaluation of progressive w...

Introduction: Pituitary tuberculosis (TB) is a rare form of intracranial TB and remains a diagnostic challenge in the absence of systemic TB. A limited number of cases has been reported in the literature.Case: A 47-year-old south Asian man presented to the accident and emergency department with complete isolated left third nerve palsy which had developed gradually over the course of a week. Brain magnetic resonance imagining (MRI) revealed a 15 mm inflam...

Introduction: Thyrotroph pituitary hyperplasia in context of severe primary hypothyroidism is rare and usually occurs due to loss of thyroxine feedback inhibition and overproduction of thyrotropin-releasing hormone, leading to pituitary gland enlargement. Pituitary hyperplasia caused by primary hypothyroidism responds well to thyroid hormone replacement therapy and rarely requires surgical intervention. Case presentation: A 42-year-old female with backgr...

Introduction: Approximately 5-10% of PHPT cases are hereditary. One such hereditary cause of PHPT is Hyperparathyroidism-jaw Tumour Syndrome (HPT-JT) caused by an autosomal dominant mutation in cell division cycle 73 (CDC73) that impairs parafibromin, a protein with antiproliferative activity. HPT-JT is characterised by parathyroid tumours, ossifying jaw fibromas, renal tumours and uterine tumours. We report a familial case of HPT-JT caused by a novel CDC73 mutation.<...